Spectroscopic Investigations of Co(II) and Cu(II) Interaction with Imatinib Mesylate and Capecitabine

Abstract

Cobalt and copper are present as trace elements in biological systems and they are very important for the activity of many enzymes. UV and FTIR spectroscopic methods are used to investigate metal ligand interactions and products of their interaction at physiological conditions. FTIR spectrum of Co(II)-capecitabine model systems show lack of absorption bands characteristic for -OH groups, indicating coordination through oxygen atoms.