Synthesis, Characterization and Interaction with CT DNA of Novel Cationic Complex Ru(III) with Indazole and Schiff Base Derived from 5-Chlorosalicylaldehyde

Abstract

Novel cationic complex compound of Ru(III) with indazole and Schiff base derived from 5-chlorosalicylaldehyde and aniline has been synthesized. Formulation and characterization of the complex was performed using CHN analysis, MALDI-TOF/TOF mass spectrometry, FT-IR spectroscopy and UV/Visible spectrophotometry. In the octahedral environment of Ru(III), coordination of bidentate Schiff bases occurs through azomethine nitrogen and deprotonated phenolic oxygen while in indazole via nitrogen atom. The interaction of the complex with CT DNA (calf thymus DNA) was carried out under physiological conditions using spectrophotometric titration.