Correlation Between Hemoglobin A1c and Lipid Profile in Bosnian Diabetic Patients—Gender Differences

Abstract

The prevalence of Type 2 diabetes mellitus (T2D) as a metabolic disease is rapidly rising worldwide. The purpose of this study was to determine concentrations of hemoglobin A1c (HbA1c), fasting glucose, and lipid profile in a total of 104 adults, 24 patients with newly diagnosed Type 2 diabetes (40-60 years of the age), 40 Type 2 diabetes, and 40 healthy subjects as control group (the same ages). On the basis of these results, we were able to assess the differences due to gender and age in tested population as well as the relationship between glycemic control (HbA1c) and serum lipid profile. Therefore, we properly evaluated the importance of HbA1c as an indicator of dyslipidemia in patients with T2D in selected Bosnian population. Hemoglobin A1c was determined by immunoturbidimetric assay, while fasting glucose and lipid profile were analyzed according to standard clinical methods on BT PLUS 2000-Biotechnic Instruments Bioanalyzer. We found that glycated hemoglobin concentrations in newly diabetic subjects were higher than those in other two groups. Statistically significant differences between study populations were seen at the level of glucose, cholesterol, HDL and LDL cholesterol, HbA1c, triacylglycerol and patient age. Also, our results have shown the significant negative correlation between HbA1c and cholesterol and HDL levels (p^***<0.001) while positive correlation was observed with glucose and patient age (p^***<0.001) in all study groups. According to our results, hemoglobin A1c can also be used as a predictor of dyslipidemia and thus early diagnosis of dyslipidemia can be used as a preventive measure for the development of cardiovascular diseases in patients with Type 2 diabetes mellitus.r.