Evaluation of Nicotine Transdermal Patches Available on the Domestic Market

Abstract

The use of transdermal patches with nicotine is a better way to quit smoking because it ensures a similar concentration of nicotine in the blood as when smoking and reduces the morning desire for a cigarette. The aim of this work was to analyze the behavior of the matrix with the active substance under conditions that are close to skin conditions. A total of 3 samples were collected from local market. The analysis was performed after 0.5, 1, 4, 10, 16 and 24 hours for each sample. The concentration of released nicotine for samples at 50 RPM ranged in the following range: sample 1 43.87%–115.23%; sample 2 40.56%–114.70%; sample 3 43.53%–117.13%. The concentration of released nicotine for the samples at 100 RPM ranged in the following range: sample 1 45.14%–120.82%; sample 2 49.05%–120.79%; sample 3 44.73%–118.51%. It was determined that most of the nicotine is released already after 4 hours. The samples also show very similar concentration results after 10 hours, and for all three samples the result was 0.096 mg/ml.